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Analytical Chemist / Biochemist

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Date: Jan 8, 2019

Location: Bethlehem, Pennsylvania, US, 18017

Company: Lubrizol Corporation

 

Particle Sciences, A Lubrizol Company is the leading CDMO for complex formulation development for the pharmaceutical industry, with over 20 years of successful experience and a solid base of clients ranging from the world’s largest pharmaceutical and biotech companies to small VC backed start-ups. As a member of the Particle Sciences, Inc. team, you will be working for a company that is engaged in important, exciting, and socially relevant projects. Particle Sciences is a fast-paced environment that features a variety of projects, technical challenges, and opportunities for growth. To learn more about Particle Sciences, A Lubrizol Company, visit www.particlesciences.com and https://www.lubrizol.com/Life-Sciences.

 

The Analytical Chemist/Biochemist will provide technical guidance, solve problems, and make a hands-on contribution from R&D method development through GLP/GMP method execution in a fast-paced CRO/CMO environment.  This position requires a chemist with knowledge and demonstrated abilities in the application of characterization methods for biologics within complex nanoparticulate formulations.  The types of biologic characterization methods range from UV protein quantitation to cell-based assays.  In addition, the Analytical Chemist/Biochemist will contribute to the characterization of small molecule APIs within complex dosage forms.  The Analytical Chemist/Biochemist will spend approximately half of their time in a project support and laboratory organization role.  The majority of the work is laboratory based and the ability to perform analytical tests within the laboratory, execute experiments per plans that have been developed together with management, and interpret and communicate the results is critical.  The Analytical Chemist/Biochemist will work independently and manage their own work within projects and assigned systems.

 

Responsibilities:

  • Execute analytical methods flawlessly in a GxP environment.
  • Evaluate, troubleshoot and transfer analytical methods for biological and small molecules within complex dosage forms.
  • Develop and validate analytical methods under the guidance of management or senior Analytical Chemists.
  • Design and execute forced degradation, excipient compatibility, and stability experiments for large biological and small drug molecules, and their product formulations
  • Utilize cell culture methods, cell binding and metabolic analyses for the analytical testing of product formulations
  • Evaluate and interpret analytical data and communicate results to management and functional teams.
  • Anticipate, recognize, and resolve simple and complex technical issues through knowledge, use of technical resources including technical literature and experts and well formulated, logical experimentation
  • Write and review SOPs, where appropriate
  • Manage analytical project work. Establish schedules, define priorities, and coordinate activities of other scientists and non-scientists as well as provide training and development for others, where appropriate.
     

Qualifications:

  • Minimum of 2 years of biopharmaceutical, vaccine and/or pharmaceutical laboratory experience in analytical R&D
  • Knowledge of cGMPs, GLPs, and FDA/ICHHHHbHHH guidelines and their application to drug product development
  • Technical expertise in running analytical methods using common biochemical techniques including ELISA, SDS-PAGE, Western blots, dot blotting, protein purification, immuno-assays, cell culture, cellular assays including:  cell binding assays, metabolic and cytotoxic assays. UPLC/HPLC-UV/FL/ELSD/MS, UV/Vis, GC, and wet chemistry experience is also beneficial. Working experience with characterization, such as product potency assays and purity/stability analyses.
  • Experience with a range of drug product dosage forms such as tables, capsules, device/implants, injectable solutions and nanosuspensions, lyophilized products, and novel formulation types is preferred
  • Experience with a range of analyte types such as proteins, peptides, carbohydrates, polysaccharides, lipids, nucleic acids and small molecule drugs.
  • Excellent problem solving and organization skills
  • The ability to manage multiple projects simultaneously, set priorities, and meet key deadlines
  • Exceptional written and verbal communication
  • Capable of working independently
  • BS/BA in a biochemical field

 

Particle Sciences’ headquarters is located in Bethlehem, PA, part of the Lehigh Valley region of Pennsylvania. Lehigh Valley includes the cities of Allentown, Bethlehem and Easton. The region is slightly over an hour to both Philadelphia and New York City, which places you right in the action. Buzzing with business, culture, knowledge and entertainment, the Lehigh Valley is a vibrant place for people of all ages and walks of life to live, learn, work and play.  This region offers a little bit of everything for everyone - ethnically-diverse communities, affordable housing, award-winning schools and universities, world-class healthcare, ski resorts, museums, casinos, shopping, restaurants, sports and nightlife. From the yearly Musikfest festival, to skiing in the Poconos, to hiking or biking through the many state parks, you can make it happen right here in the Lehigh Valley.

 

Lubrizol is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to sex, race, color, national origin, citizenship, age, religion, marital status, military service, sexual orientation, genetic information, gender identity, or any other characteristic or trait protected by federal, state, or local law.


Nearest Major Market: Allentown

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